Vincent Price as Charles Dexter Ward / Joseph Curwen

Debra Paget as Ann Ward

Lon Chaney Jr. as Simon Orne

Frank Maxwell as Dr. Marinus Willet / Priam Willet

Leo Gordon as Edgar Weeden / Ezra Weeden

Elisha Cook Jr. as Gideon Smith / Micah Smith

John Dierkes as Benjamin West / Jacob West

Milton Parsons as Jabez Hutchinson

Cathie Merchant as Hester Tillinghast

Guy Wilkerson as Gideon Leach / Mr. Leach

Barboura Morris as Mrs. Weeden

I. Stanford Jolley as Carmody, Coachman

Harry Ellerbe as Minister

Darlene Lucht as Miss Fitch

Bruno VeSota as Bruno, the Bartender

Jack Tornek as Lynch Mob Member (uncredited)

Nina Borget as Villager (uncredited)

Albert Cavens as Villager (uncredited)

Charles Fogel as Villager (uncredited)