Robert De Niro as The Creature / Sharp Featured Man

Kenneth Branagh as Victor Frankenstein

Tom Hulce as Henry Clerval

Helena Bonham Carter as Elizabeth

Aidan Quinn as Cap. Robert Walton

Ian Holm as Baron Frankenstein

Richard Briers as Grandfather

John Cleese as Prof. Waldman

Robert Hardy as Prof. Krempe

Cherie Lunghi as Caroline Beaufort Frankenstein

Celia Imrie as Mrs. Moritz

Trevyn McDowell as Justine

Mark Hadfield as Felix

Gerard Horan as Claude

Joanna Roth as Marie

Alfred Bell as Landlord

Sasha Hanau as Maggie

Joseph England as Thomas

Richard Clifford as Minister

George Asprey as Policeman

Hugh Bonneville as Schiller

Ryan J-W Smith as William

Charles Wyn-Davies as Young William

Rory Jennings as Young Victor

Christina Cuttall as Young Justine

Hannah Taylor-Gordon as Young Elizabeth

Susan Field as Frau Brach

Jimmy Yuill as Greigori

Chris Barnes as Ship's Crew

Shaun Prendergast as Ship's Crew

Tommy Wright as Ship's Crew

David Kennedy as Ship's Crew

Paul Gregory as Ship's Crew

Chris Hollis as Ship's Crew

Robin Lloyd as Ship's Crew

Alex Lowe as Ship's Crew

Graham Loughridge as Ship's Crew

Simon Cox as Ship's Crew

Robert Hines as Ship's Crew

Lonnie James as Rough Woman

Jenny Galloway as Vendor's Wife

Peter Jonfield as Rough Man

Edward Jewesbury as City Official

Siobhan Redmond as Midwife

Francine Morgan as Assistant Midwife

Sue Long as Woman in Labor

Michael Gould as Stablehand

Angus Wright as Guard

Max Gold as Servant

Abigail Reynolds as Mansion Staff

Theresa Fresson as Mansion Staff

Mark Inman as Mansion Staff

Dudi Appleton as Mansion Staff

Meriel Schofield as Mansion Staff

Jim Carter as Executioner (uncredited)