Paul Bettany as Charles Darwin

Jennifer Connelly as Emma Darwin

Martha West as Anne Darwin

Guy Henry as Technician

Jeremy Northam as John Brodie-Innes

Toby Jones as Thomas Henry Huxley

Benedict Cumberbatch as Joseph Dalton Hooker

Jim Carter as Parslow

Robert Glenister as Dr. Holland

Ian Mercer as Goodman

Bill Paterson as Dr. Gully

Teresa Churcher as Mrs. Davies

Richard Ridings as Thatcher

Freya Parks as Etty Darwin

Ian Kelly as Captain Fitzroy

Anabolena Rodriguez as Fuegia Basket

Paul Campbell as Boat Memory

Zak Davies as Jemmy Button

Christopher Dunkin as George Darwin

Gene Goodman as Franky Darwin

Harrison Sansostri as Lenny Darwin