Sam Rockwell as Don Verdean

Jemaine Clement as Boaz

Amy Ryan as Carol

Danny McBride as Tony Lazarus

Will Forte as Pastor Fontaine

Leslie Bibb as Joylinda Lazarus

Steve Park as Poon-Yen

Sky Elobar as Dr. Stanley

Yaniv Moyal as Israeli Police Officer

P.J. Boudousqué as Gary

Jared Shipley as Lab Tech

Jake Van Wagoner as Police Officer

Logan Rogan as Tourist

Michael Flynn as Church Elder

Pete Rockwell as Antique Store Owner

Harry Bonner as Security Guard

Stelios Xanthos as Shem

Deborah Lee Douglas as Sarah (uncredited)

Connor Williams as Rude Teen (uncredited)

Ricky Egan as Lecture Listener (uncredited)

Jeremy Warner as Reporter (uncredited)

Justin Chapman as Helicopter Pilot