Hayley Mills as Pollyanna

Jane Wyman as Aunt Polly

Richard Egan as Dr. Edmond Chilton

Karl Malden as Reverend Paul Ford

Nancy Olson as Nancy Furman

Adolphe Menjou as Mr. Pendergast

Donald Crisp as Mayor Karl Warren

Agnes Moorehead as Mrs. Snow

Kevin Corcoran as Jimmy Bean

James Drury as George Dodds

Reta Shaw as Tillie Lagerlof

Leora Dana as Mrs. Ford

Anne Seymour as Amelia Tarbell

Edward Platt as Ben Tarbell

Mary Grace Canfield as Angelica

Jenny Egan as Mildred Snow

Gage Clarke as Mr. Murg

Ian Wolfe as Mr. Neely

Nolan Leary as Mr. Thomas

Edgar Dearing as Mr. Gorman

Arthur Tovey as Fishing Booth Attendant (Uncredited)

Paul Frees as Barker (Voice) (Uncredited)

Jack Deery as Townsman (Uncredited)

Stephanie Gorman as Girl Singing 'America, America' (Uncredited)

Tim Graham as Orphanage Worker (Uncredited)

Signe Hack as Townswoman (Uncredited)

Harry Harvey as Editor (Uncredited)

Harvey Karels as Party Guest (Uncredited)

Jon Lormer as Mr. Geary (Uncredited)

Hans Moebus as McEnerney, Dress Shop Manager (Uncredited)

William Newell as Mr. Hooper (Uncredited)

Jean Ransome as Townswoman (Uncredited)

Fred Rapport as Townsman (Uncredited)

Charles Seel as Train Conductor (Uncredited)

George Sowards as Wagon Driver (Uncredited)

David Swift as Fireman (Uncredited)

Paul Cristo as Townsman (uncredited)

Cathy Ann Bisutti as Girl Singing (uncredited)

Arthur Lovejoy as Townsman (uncredited)