Richard Dreyfuss as Prof. Krippendorf

Jenna Elfman as Veronica

Zakes Mokae as Sulukim

Siobhan Fallon Hogan as Lori

Natasha Lyonne as Shelly

Gregory Smith as Mickey

Lily Tomlin as Ruth Allen

Stephen Root as Gerald Adams

Elaine Stritch as Irene Hargrove

Mila Kunis as Abbey Tournquist

David Ogden Stiers as Henry Spivey

Doris Belack as President Porter

Julio Oscar Mechoso as Simon Alonso

Amzie Strickland as Gladys Schmades

Phil Leeds as Dr. Harvey

Frances Bay as Edith Proxmire

Susan Ruttan as Mrs. O'Brian

Tom Poston as Gordon Hargrove

Penny Johnson Jerald as Teacher

Bruce Jarchow as Dr. Andrews, Chester Hill

Wendy Worthington as Secretary

Carl Michael Lindner as Edmund

Barbara Williams as Jennifer

Sandy Martin as Nurse

Lance Kinsey as Principal Reese

Robin Karfo as Mrs. Tournquist

Tim Halligan as Mr. Tournquist

Peter Tilden as Larry Swift

Shashawnee Hall as Mabu

Timothy Wells as Ruth's Guide

Kari Leigh Floyd as Party Guest

Michael Steve Jones as Alcove Man

Ian Busch as Flagpole Boy

Grace Lee as College Student #1

Todd Cattell as College Student #2

Jacob Handy as Young Edmund

Zachary Handy as Young Edmund

Chris Duque as Outpost Man

Valerie Reid as Divorced Woman

Rachel Winfree as Lecture Woman #1

Suanne Spoke as Lecture Woman #2

Catherine Paolone as Lecture Woman #3

Bill Rosier as TV Store Customer #1

Robb Derringer as TV Store Customer #2

Laura Cayouette as TV Studio Woman

China Brezner as Elevator Teen

Joy Somers as Carol's Friend (uncredited)