Christopher Abbott as James White

Cynthia Nixon as Gail White

Kid Cudi as Nick

Makenzie Leigh as Jayne

Ron Livingston as Ben

David Call as Elliot

Scott Cohen as Barry White

Jeanette Dilone as Irene

David Harris as Joe

Sue Jean Kim as Karen

Rachel Brosnahan as Ellen

Bhavesh Patel as Dr. Lobo

Jessica Wong as Jesse

Benjamin Bass as Leland

Laura Johnston as Genie

David Cale as Grief Counselor

Margarita Levieva as Secretary

Zazie Beetz as Girl #1

Jasmin Gabrielle as Girl #2

Betsy Aidem as Woman

Richard Topol as Pharmacist

Adriana DeGirolami as Waitress

David Deblinger as Man

Khalil Muhammad as Club Guy

Patrick Murney as Bartender

Linda Powell as Nurse #1

Rosemary Howard as Nurse #2

Hubert Point-Du Jour as EMT #1

Bradley Fleischer as EMT #2

Patrick M. Walsh as Bar Patron #1

Rodrigo Lopresti as Bar Patron #2