Tadao Takashima as Dr. Yuzo Kawaji

Nick Adams as Dr. James Bowen

Kumi Mizuno as Dr. Sueko Togami

Yoshio Tsuchiya as Daigo Kawai

Koji Furuhata as Frankenstein

Jun Tazaki as Hideo Nishi, Director of the Okayama Prefectural Police

Susumu Fujita as Osaka Prefectural Police Chief

Takashi Shimura as Hiroshima Army Hospital doctor

Nobuo Nakamura as Dr. Suga

Kenji Sahara as Tadokoro, Bowen's assistant

Hisaya Itō as Osaka Police Sergeant

Yoshibumi Tajima as Murata, Japanese Imperial Navy submarine captain

Kōzō Nomura as Newspaper Reporter

Haruya Katō as TTV Director

Ikio Sawamura as Housekeeper

Yoshio Kosugi as JSDF Executive

Keiko Sawai as Tsuruko Toida

Noriko Takahashi as Girl in Shirane hut

Peter Mann as Dr. Liesendorf

Ren Yamamoto as Motoki

Yutaka Sada as Hospital Secretary

Kenzō Tabu as Newspaper Employee

Shigeki Ishida as University Professor

Haruo Nakajima as Baragon / JSDF Soldier

Yutaka Nakayama as TTV Lighting man

Senkichi Ōmura as TTV Lighting man

Nadao Kirino as Okabe policeman

Shin Ōtomo as Sugiyama policeman

Shōichi Hirose as Tunnel Worker

Toshihiko Furuta as Farmer

Hideo Shibuya as Reporter

Tadashi Okabe as Sarcastic Reporter

Hideaki Nitani as Hospital Official (uncredited)

Saburô Iketani as Reporter (uncredited)

Kenichiro Kawaji as Young Frankenstein

Kazuo Kumakura as Dr. Lisendorf (voice)

Gorō Naya as Dr. Bowen (voice)