Sushant Singh Rajput as Byomkesh Bakshy

Anand Tiwari as Ajit Kumar Banerjee

Neeraj Kabi as Dr. Anukul Guha

Divya Menon as Satyavati

Swastika Mukherjee as Anguri Devi

Meiyang Chang as Kanai Dao

Mark Bennington as Deputy Commissioner Wilkie

Takanori Higuchi as Dr. Watanabe

Kausik Ghosh as Gajanan Sikdhar

Anindya Pulak Banerjee as Prafulla Ray

Arindol Bagchi as Ashwini Babu

Peter Wong as Chinese Underboss

Pradipto Kumar Chakraborty as Puntiram

Manoshi Nath as Ruby

Moumita Chakraborty as Leela

Tirtha Mallick as Atanu Chandra Sen

Shaktipada Dey as Nibaran Da

Prasun Gain as Journalist

Aryann Bhowmick as Young Revolutionary

Nishant Kumar as Factory Watchmen

Prashant Kumar as Factory Watchmen

Sandip Bhattacharya as Officer in Charge

Piyali Ray as Watanabe's Receptionist

Lauren Gottlieb as Special Appearance in "Calcutta Kiss" Song