Sally Field as Doris Miller

Max Greenfield as John Fremont

Beth Behrs as Brooklyn

Stephen Root as Todd

Natasha Lyonne as Sally

Kumail Nanjiani as Nasir

Wendi McLendon-Covey as Cynthia

Rich Sommer as Robert

Peter Gallagher as Willy Williams

Tyne Daly as Roz

Elizabeth Reaser as Dr. Edwards

Isabella Acres as Vivian

Kyle Mooney as Niles

Caroline Aaron as Val

Rebecca Wisocky as Anne

Amy Okuda as Des

Don Stark as Uncle Frank

Nnamdi Asomugha as Shaka

Anna Akana as Blog Girl

Emilie Germain as Stevie

Jack Antonoff as Baby Goya

Sofia Hasmik as Ines

Rayman Jilani as Office Cubicle Worker

Catherine Kresge as Fiona

A.J. Ackleson as Hipster Turkey Man

Lee Chen as Nurse #1

Kale Clauson as Pink Guy

Kate Comer as Hipster Girl

Bren Coombs as Hipster

Sharon Fredrickson as Willow

Tatiana Golykh as Office worker

Nick Hentsch as Record Store Patron

Abraham Lim as Kris

Edmund Lupinski as Priest

Norma Michaels as Doris's Mother

Renna Nightingale as Indie Girl

Eric Pumphrey as Indie Guy

Brenna Rhea as Punk Girl

Roz Ryan as Nurse 2

Guilherme Scarabelot as Keith

Shondale Seymour as Book Seller

Leilani Marie Smith as Jogger - Dayplayer

Michael Terra as Sawyer

Susan Ziegler as Prim Organizer