Richard Widmark as Lt. Cmdr. Clinton 'Clint' Reed M.D.

Paul Douglas as Capt. Tom Warren

Barbara Bel Geddes as Nancy Reed

Jack Palance as Blackie

Zero Mostel as Raymond Fitch

Dan Riss as Neff - Newspaper Reporter

Tommy Cook as Vince Poldi - Younger Brother

Wilson Bourg Jr. as Charlie - Sailor (uncredited)

Beverly C. Brown as Dr. Mackey - Board of Health (uncredited)

Lewis Charles as Kochak - Murder Victim (uncredited)

Herman Cottman as Officer Scott - Police Lab (uncredited)

John David as Fruit Salesman (uncredited)

William A. Dean as Cortelyou (uncredited)

Robert Dorsen as Coast Guard Lieutenant (uncredited)

George Ehmig as Kleber - Medical Examiner Technician (uncredited)

H. Waller Fowler Jr. as Mayor Murray (uncredited)

Paul Hostetler as Lt. Paul Gafney M.D. - Public Health Service (uncredited)

Elia Kazan as Cleaver - Mortuary Assistant (uncredited)

Edward Kennedy as Jordan (uncredited)

Mary Liswood as Angie Fitch - Raymond's Wife (uncredited)

Henry Mamet as Anson (uncredited)

Tiger Joe Marsh as Bosun on Nile Queen (uncredited)

Ruth Moore Mathews as Mrs. Dubin (uncredited)

Emile Meyer as Capt. Beauclyde - Master of Nile Queen (uncredited)

Alex Minotis as John Mefaris - Restaurant Owner (uncredited)

Rex Moad as Wynant (uncredited)

Ray Müller as Dubin (uncredited)

Lenka Peterson as Jeanette - Charlie's Girlfriend (uncredited)

Waldo Pitkin as Ben (uncredited)

Tommy Rettig as Tommy Reed (uncredited)

Stanley J. Reyes as Redfield (uncredited)

John Schilleci as Lee (uncredited)

Al Theriot as Al (uncredited)

Guy Thomajan as Poldi - Blackie's Flunky (uncredited)

Arthur Tong as Lascar Boy on Nile Queen (uncredited)

H.T. Tsiang as Cook on Nile Queen (uncredited)

Irvine Vidacovich as Johnston (uncredited)

Juan Villasana as Hotel Proprietor (uncredited)

Pat Walshe as Pat - Newspaper Peddler (uncredited)

Val Winter as Commissioner Dan Quinn (uncredited)

Leo Zinser as Sgt. Phelps (uncredited)

Aline Stevens as Rita Mefaris (uncredited)