Benjamin Bratt as Superman / Hernan Guerra (voice)

Michael C. Hall as Batman / Kirk Langstrom (voice)

Tamara Taylor as Wonder Woman / Bekka (voice)

Jason Isaacs as Lex Luthor (voice)

C. Thomas Howell as Dr. Will Magnus (voice)

Paget Brewster as Lois Lane (voice)

Kari Wahlgren as Karen Beecher / Livewire (voice)

Grey DeLisle as Tina / Platinum (voice)

Larry Cedar as Pete Ross (voice)

Eric Bauza as Ryan Choi / Stephen Shin (voice)

Penny Johnson Jerald as President Waller (voice)

Dee Bradley Baker as Ray Palmer / Tin (voice)

Richard Chamberlain as Highfather (voice)

Trevor Devall as Emil Hamilton (voice)

Dan Gilvezan as Pat Dugan (voice)

Daniel Hagen as Dr. Sivana (voice)

Josh Keaton as Orion (voice)

Arif S. Kinchen as Michael Holt / Bronze Tiger (voice)

Yuri Lowenthal as Jor-El / Jimmy Olsen (voice)

Carl Lumbly as Silas Stone (voice)

Jim Meskimen as Victor Fries (voice)

Tayla Parx as Victor Stone (voice)

Khary Payton as John Henry Irons / Granny Goodness / Mugger (voice)

Tahmoh Penikett as Steve Trevor (voice)

Andrea Romano as Jean Palmer (voice)

André Sogliuzzo as Cop / Mr. Guerra (voice)

Bruce Thomas as General Zod / Darkseid (voice)

Lauren Tom as Lara Lor-Van (voice)

Marcelo Tubert as Tough Guy (voice)

Bruce Timm as Blockbuster (voice) (uncredited)