Katie Holmes as Carla

Luke Kirby as Marco

Griffin Dunne as George

Bruce Altman as Donald

Annie Golden as Motherly Patient

Chaske Spencer as Marco's Construction Boss

Maryann Urbano as Dr. Strinsky

Christine Lahti as Sara

Celeste Lecesne as Man at Book Reading

Angela Pierce as Book Reading Attendant

Patrick Byas as Demonix

Roca as Ravenous

Jennifer Falu as Nyorican MC

Kim Rosen as Hospital Receptionist

Stephen Beach as Police Officer

Rachel Zeiger-Haag as Hospital Waiting Room Receptionist

Paul Dalio as Paul

Marcy Harriell as Psych Ward Nurse

Ted Sod as Bible Scholar Patient

Rob Leo Roy as Gary

James Miles as Marker Tattooing Patient

Edward Gelbinovich as Paranoid Patient

Catherine Combs as Tarot Reading Patient

Mike Faist as Additional Psych Ward Patient

Russell G. Jones as Group Therapist

Brent Bateman as Night Nurse

Rob Gorden as Springtime Psych Ward Receptionist

Daniel Gerroll as Dr. Lyon

Joseph Adams as Administrator of Second Hospital

Victoria Weinberg as Carla and Marco's New Female Dinner Friend

Bobby Kruger as Carla and Marco's New Male Dinner Friend

Kay Redfield Jamison as Self

Wayne Wilcox as Carla's New Boyfriend

Erick Abbate as Sammy (uncredited)

Genevieve Adams as Susan (uncredited)

Brett Berg as The Poetry Heckler (uncredited)

Jasmine Hope Bloch as Poetry Cafe Patron (uncredited)

Greg Oliver Bodine as Heckler (uncredited)

Jim Ford as Police Officer (uncredited)

Rosemary Howard as Audience at Reading of Faded (uncredited)

Anna Kuchma as Mother of the Young Child (uncredited)

Alex Manette as Eddy (uncredited)

Jon Douglas Rainey as Book Club Member (uncredited)

Nancy Ellen Shore as Literary Intellectual (uncredited)

Reginald L. Wilson as Club Patron (uncredited)