Dennis Hopper as Milo

Jodie Foster as Anne Benton

Dean Stockwell as John Luponi

Vincent Price as Mr. Avoca

John Turturro as Pinella

Fred Ward as Pauling

Julie Adams as Martha

Tony Sirico as Greek

Charlie Sheen as Bob

Catherine Keener as Trucker's Girl

Sy Richardson as Capt. Walker

Frank Gio as Frankie

Satya De La Manitou as Car Thug

Helena Kallianiotes as Grace Carelli

John Apicella as Man at Refinery

Katherine LaNasa as Waitress

Anthony Pena as Taos Sheriff

Sarina C. Grant as Hooker

Tomás Goros as Golf Course Fed

Lauren Lloyd as Margaret Mason

Michael Yama as Technician

Bob Dylan as Artist (uncredited)

Joe Pesci as Leo Carelli (uncredited)

Ted Markland as Man in Van (uncredited)

Toni Basil as (uncredited)

Alex Cox as D.H. Lawrence (uncredited)

David E. Harshbarger as Free Base Cocaine User (uncredited)

Grand L. Bush as Bank Teller (as Grand Bush)

Robert Rothwell as Ad Agency Exec

Kevin Bourland as Ad Agency Man

Debbie David as Ad Agency Man (as Carl David Burks)

Burke Byrnes as Fed #1

Tod Davies as Hit Woman

Jerry Summers as Rianetti

John Zenda as Trucker

Ellie Wood Walker as Woman in Van (uncredited)