Diane Keaton as Charlotte Cooper

John Goodman as Sam Cooper

Ed Helms as Hank Cooper

Amanda Seyfried as Ruby

Alan Arkin as Bucky Newport

Steve Martin as Rags (voice)

Olivia Wilde as Eleanor Cooper

Marisa Tomei as Emma Newport

Jake Lacy as Joe Bailey

June Squibb as Aunt Fishy

Alex Borstein as Angie Cooper

Anthony Mackie as Officer Percy Williams

Timothée Chalamet as Charlie Cooper

Blake Baumgartner as Madison Cooper

Maxwell Simkins as Bo Cooper

Dan Amboyer as Jake

Jon Tenney as Dr. Morrissey

Molly Gordon as Lauren Hesselberg

Dorothy Silver as Mrs. Pinkins

Larry McKay as Bob

Sylvia Kauders as Sara

Krista Marie Yu as Lily

Keenan Jolliff as Brady

Kristin Slaysman as Effie Newport

Michael R. Wilson as Young Sam

Elisabeth Evans as Young Charlotte

Quinn McColgan as Young Charlotte (12-14 Yrs)

Sean McGee as Young Bucky

Rory Wilson as Young Emma

Michelle Veintimilla as Kendra

Joe Fishel as Dog Owner

Richard C. Fishel as Dog

Lev Pakman as Schnozzle Whitehead