Sidney Toler as Charlie Chan

Victor Sen Yung as Jimmy Chan

Cesar Romero as Fred Rhadini

Douglas Fowley as Peter Lewis

Pauline Moore as Eve Cairo

Donald MacBride as Deputy Police Chief J.J. Kilvaine

Douglass Dumbrille as Stewart Salsbury, alias Thomas Gregory

Trevor Bardette as Dr. Zodiac's Servant

Gerald Mohr as Dr. Zodiac (in disguise)

Wally Vernon as Elmer

June Gale as Myra Rhadini

Billie Seward as Mrs. Bessie Sibley

Sally Blane as Stella Essex

Charles Halton as Uncle Redley

Louis Jean Heydt as Paul Essex

Jack Chefe as Audience Member

Heinie Conklin as First Taxicab Driver

Sayre Dearing as Audience Member

Bud Geary as Cop at Station House

Harold Goodwin as Airplane Steward

Edith Hallor as Toots - Stout Woman

Fred Kelsey as Detective - in Cab and at Theatre

Al Kikume as Waiter at Hawaiian Village

Kay Linaker as Egyptian Princess Ectoplasm

Hank Mann as Second Taxicab Driver

Margaret Mann as Airplane Passenger

Frank Meredith as Second Detective

Harold Miller as Audience Member

Bruce Mitchell as Police Desk Sergeant

Hans Moebus as Audience Member

Bert Moorhouse as Audience Member

David Newell as Audience Member

Imboden Parrish as Plane Passenger

Tom Quinn as Man at Landing Gate

Arthur Rankin as Airways Official

Fred Rapport as Audience Member

Gloria Roy as Plane Passenger

Jeffrey Sayre as Man at Landing Gate

Harry Strang as Taxicab Dispatcher

Charles Tannen as Plane Passenger

Edwin Tuttle as Audience Member

John Elliott as Doctor - Backstage