Tom Cruise as Frank T.J. Mackey

Philip Baker Hall as Jimmy Gator

Philip Seymour Hoffman as Phil Parma

Julianne Moore as Linda Partridge

William H. Macy as Quiz Kid Donnie Smith

John C. Reilly as Officer Jim Kurring

Melora Walters as Claudia Wilson Gator

Jeremy Blackman as Stanley Spector

Jason Robards as Earl Partridge

Melinda Dillon as Rose Gator

Michael Bowen as Rick Spector

April Grace as Gwenovier

Ricky Jay as Burt Ramsey / Narrator

Emmanuel Johnson as Dixon

Pat Healy as Sir Edmund William Godfrey / Young Pharmacy Kid

Genevieve Zweig as Mrs. Godfrey

Mark Flanagan as Joseph Green

Neil Flynn as Stanley Berry

Rod McLachlan as Daniel Hill

Allan Graf as Firefighter

Patton Oswalt as Delmer Darion

Raymond 'Big Guy' Gonzales as Reno Security Guard

Brad Hunt as Craig Hansen

Jim Meskimen as Forensic Scientist

Chris O'Hara as Sydney Barringer

Clement Blake as Arthur Barringer

Frank Elmore as 1958 Detective

John Kraft Seitz as 1958 Policeman

Cory Buck as Young Boy

Tim Soronen as Infomercial Guy

Jim Ortlieb as Middle-Aged Guy

Thomas Jane as Young Jimmy Gator

Holly Houston as Jimmy's Showgirl

Benjamin Niedens as Little Donnie Smith

Veronica Hart as Dentist Nurse #1

Missy Spell Tanner as Dentist Nurse #2

James Kiriyama-Lem as Dr. Lee

Jake Cross as Pedestrian #1

Charlie Scott Jr. as Pedestrian #2

Juan Medrano as Nurse Juan

John Pritchett as Police Captain

Cleo King as Marcie

Don McManus as Dr. Landon

Michael Shamus Wiles as Captain Muffy

Jason Andrews as Doc

John S. Davies as Cameraman

Kevin Breznahan as Geoff, Seminar Guy

Miguel Pérez as Avi Solomon

Alfred Molina as Solomon Solomon

David Masuda as Coroner Man

Neil Pepe as Officer #1

Lionel Mark Smith as Detective

Annette Helde as Coroner Woman

Lynne Lerner as Librarian

Felicity Huffman as Cynthia

Scott Burkett as WDKK Page #1

Bob Brewer as Richard's Dad

Julie Brewer as Richard's Mom

Nancy Marston as Julia's Mom

Maurey Marston as Julia's Dad

Jamala Gaither as WDKK P.A.

Danny Wells as Dick Jennings

Amy Brown as WDKK Page #2

Eileen Ryan as Mary

Meagen Fay as Dr. Diane

Patricia Forte as Mim

Luis Guzmán as Luis

Patrick Warren as Todd Geronimo

Orlando Jones as Worm

Virginia Pereira as Pink Dot Girl (voice)

Craig Kvinsland as Brad the Bartender

Patricia Scanlon as Cocktail Waitress

Henry Gibson as Thurston Howell

Natalie Elizabeth Marston as Julia

Bobby Brewer as Richard

Clark Gregg as WDKK Floor Director

Art Frankel as Old Pharmacist

Matt Gerald as Officer #2

Guillermo Melgarejo as Pink Dot Guy

Paul F. Tompkins as Chad (Seduce & Destroy) (voice)

Mary Lynn Rajskub as Janet (Frank's Assistant) (voice)

Jim Beaver as Smiling Peanut Patron #1

Ezra Buzzington as Smiling Peanut Patron #2

Denise Woolfork as Smiling Peanut Patron #3

Michael Murphy as Alan Kligman, Esq.

Robert Downey Sr. as WDKK Show Director

William Mapother as WDKK Show Director's Assistant

Larry Ballard as WDKK Medic

Brett Higgins as Mackey Disciple Twin #1

Brian Higgins as Mackey Disciple Twin #2

Michael Lee Phillips Jr. as Mackey Disciple in Middle

Lillian Adams as Donnie's Old Neighbor

Steven Bush as Paramedic #1

Mike Massa as Paramedic #2

Dale Gibson as Paramedic #3

Scott Alan Smith as E.R. Doctor

Paul Thomas Anderson as Man Confiscating Sign (uncredited)

Miriam Margolyes as Faye Barringer (uncredited)

Bruno Angelico as Fireman #2 (uncredited)

Robert Bella as Detective #2 (uncredited)

Greg Bronson as Waiter (uncredited)

Douglas Busby as Extra (uncredited)

Marc Davies as Seminar Attendee #1 (uncredited)

Bruce Gregory as Randy (uncredited)

Phil Hawn as Bob (uncredited)

Spencer Kayden as Seminar Patron (uncredited)

Brian Kehew as Seminar Patron (uncredited)

Michael Laren as Officer Tom 1958 (uncredited)

Aimee Mann as Hot Date Infomercial (uncredited)

Tom Ohmer as Detective (uncredited)

Colleen Pelletier as Gameshow Audience Member (uncredited)

Herb Santos Jr. as 21 Dealer (uncredited)

Tom Tangen as Drunken Dart Player (uncredited)