Claire Danes as Temple Grandin

David Strathairn as Professor Carlock

Barry Tubb as Randy

Melissa Farman as Alice

Charles Baker as Billy

Blair Bomar as Ellen

Cherami Leigh as Marcia

Tamara Jolaine as Nancy

Julia Ormond as Eustacia

David Born as Professor Shanklin

Catherine O'Hara as Aunt Ann

Chloë Evans as Dorothy

Jordan Strassner as Science Student

Michael D. Conway as Mr. Peters

Xochitl Romero as Penelope

Joe Nemmers as Mr. Neal

Richard Dillard as Don Micheals

David Blackwell as Small Store Clerk

Toby Metcalf as Stacey

Brady Coleman as Abbot Chief Exec.

Silver Renee as Kid / Patient in Waiting Room

Chad McMinn as Graduating Student

Nicole Holt as Autism Symposium Attendee

Jake Messinger as Pallbearer

Cynthia Huerta as Joan

Jessica Looney as Iris

Cassandra L. Small as Autism Symposium Attendee

Kurt Cole as Autism Symposium Attendee

William Akey as Mr. Hodges

Phil Harrington as Dr. Ladenham

Megan Moser as Melanie

Carl Savering as Mr. Goscowicz

Allison Wood as Asylum Nurse

Gabriel Luna as Student Wit

Brian Bentley as Scott

Clark Perry as Cody the Bully

Brett Hill as Birthday Party Boy

Max W. Jenkins as Birthday Party Guest

D.J. Castillo as Science Student

Chris Olson as Mr. Povey

Robert Newell as Henry

Cheryl Cave as Autism Symposium Attendee

Kelli Bland as Science Student / Dorm girl

David L. Dunn as Cowboy at auction

Rick Espaillat as French Lecturer

Mike Rembis as Professor of Letters

Steve Uzzell as Psychologist

David Houston as Car Dealer

Earl Nottingham as Auction Bidder

Rachel McDaniel as Autism Symposium Attendee

Robin Lee Walper as Autism Symposium Host

Patrick Bertucci as Autism Symposium Attendee

Helen Ingham as Teacher

Fred Bothwell as Airport Greeter

Kelsey Buchanan as Birthday Party Friend

Gerry Robert Byrne as John Richmond

Michael Crabtree as Uncle Mike