Nick Swardson as Remy (voice)

T.J. Miller as Augie (voice)

Mila Kunis as Deema (voice)

Bob Odenkirk as The Devil (voice)

Susan Sarandon as Barb the Angel (voice)

Danny McBride as Orpheus (voice)

Rob Riggle as Curt (voice)

Jennifer Coolidge as Durmessa (voice)

Michael Peña as Abigor (voice)

Kumail Nanjiani as Dave the Demon (voice)

JB Smoove as Sal the Demon (voice)

David Koechner as Asmodeus (voice)

Paul Scheer as Head Demon (voice)

Brian Posehn as Cleb (voice)

Kerri Kenney as Madame Zonar (voice)

H. Jon Benjamin as The Tree

Dana Snyder as Garthog (voice)

Jay Johnston as Rick (voice)

Maria Bamford as Gloria (voice)

Lance Bass as Darren (voice)

John Farley as Demon (voice)

Seth Morris as Atheist (voice)

Greg Proops as Asmoday (voice)

Kyle Kinane as Demon Head (voice)

Paul F. Tompkins as Annoyed Lost Soul