Peter Dinklage as Winston Gooze / Toxie (Voice)

Jacob Tremblay as Wade Gooze

Kevin Bacon as Bob Garbinger

Elijah Wood as Fritz Garbinger

Taylour Paige as J.J. Doherty

Julia Davis as Kissy Sturnevan

Sarah Niles as Mayor Togar

Jonny Coyne as Thad Barkabus

Macon Blair as Dennis

Atanas Srebrev as Chief Wormer

Abraham Lewis as Spence

Lee Eddy as CJ Doons

Spencer Wilding as Monster Garbinger

Annette Badland as Daisy

Sunil Patel as Dr. Walla

Rebecca O'Mara as Shelly Gooze

Lloyd Kaufman as Lloyd (The Hospital Grump)

Chris Sharp as C.S. Hawley

Shaun Dooley as Mel Ferd

Brent Werzner as Toxie Witness

Randy E. Aguebor as Coach Stanwyck

Ev Lunning as Rick Feet

David Yow as Guthrie Stockins

Jane Levy as Cheerful Insurance Rep (voice)

Luisa Guerreiro as Toxic Avenger/Toxie