Jordan Peele as Rell Williams / Oil Dresden

Keegan-Michael Key as Clarence Goobril / Smoke Dresden

Keanu Reeves as Keanu (voice)

Tiffany Haddish as Hi-C

Method Man as Cheddar

Darrell Britt-Gibson as Trunk

Jason Mitchell as Bud

Jamar Malachi Neighbors as Stitches

Luis Guzmán as Bacon

Will Forte as Hulka

Nia Long as Hannah

Rob Huebel as Spencer

Madison Wolfe as Alexis

Jordyn A. Davis as Belle

James Yeargain as Donnie

Brittany Seymour as Rachel

Richard Holden as Detective Mank

Nadiyah Skyy Taylor as Galaxy

Susan McBrien as Hulka's Mom

Jenny Ballard as Officer Jonah

Ian Casselberry as King Diaz

Neil Wells as Prison Guard

David A. Cole as Cop #1

Reginal Varice as Cop #2

Nicholas Hayner as Guard #2

Anna Faris as Self (uncredited)

Sam Medina as Cartel Leader (uncredited)

Gino Galento as Narco Guard (uncredited)

Maia Kavchak as Drug Girl (uncredited)

Sue-Lynn Ansari as Dancer (uncredited)