Boris Karloff as Dr. Fu Manchu

Lewis Stone as Nyland Smith

Karen Morley as Sheila Barton

Charles Starrett as Terence Granville

Myrna Loy as Fah Lo See

Jean Hersholt as Von Berg

Lawrence Grant as Sir Lionel Barton

David Torrence as McLeod

C. Montague Shaw as Curator Dr. Fairgyle - British Museum Official (uncredited)

Steve Clemente as Knife Thrower (uncredited)

Allen Jung as Coolie (uncredited)

Chris-Pin Martin as Potentate (uncredited)

Edward Peil Sr. as Coolie Spy (uncredited)

Willie Fung as Ship's Steward (uncredited)

E. Alyn Warren as Goy Lo Sung - Fu Manchu Messenger (uncredited)

Olive Young as Cantina singer (uncredited)

Everett Brown as Slave (uncredited)

Clinton Rosemond as Slave (uncredited)