Keanu Reeves as Bob Arctor

Robert Downey Jr. as James Barris

Woody Harrelson as Ernie Luckman

Winona Ryder as Donna Hawthorne

Rory Cochrane as Charles Freck

Mitch Baker as Brown Bear Lodge Host

Sean Allen as Additional Fred Scramble Suit Voice (voice)

Cliff Haby as Voice from Headquarters (voice)

Steven Chester Prince as Cop

Natasha Valdez as Waitress

Mark Turner as Additional Hank Scramble Suit Voice (voice)

Chamblee Ferguson as Medical Deputy #2

Angela Rawna as Medical Deputy #1

Eliza Stevens as Arctor's Daughter #1

Sarah Menchaca as Arctor's Daughter #2

Melody Chase as Arctor's Wife

Leif Anders as Freck Suicide Narrator (voice)

Turk Pipkin as Creature

Alex E. Jones as Street Prophet

Lisa Marie Newmyer as Connie

Wilbur Penn as Medical Officer #1

Ken Webster as Medical Officer #2

Hugo Perez as New Path Staff Member #1

Rommel Sulit as New Path Staff Member #2

Dameon Clarke as Mike

Ryan Melton as New Path Resident #1

Leila Plummer as New Path Resident #2

Jason Douglas as New Path Farm Manager

Marco Perella as Donald

Gary Teague as Brown Bear Lodge Member (uncredited)