Patrick Wilson as Jack MacChesney

Jane Krakowski as Sweet Sue Tinsley

Ashley Judd as Ave Maria Mulligan

Whoopi Goldberg as Fleeta Mullins

Jenna Elfman as Iva Lou Wade

Dagmara Dominczyk as Elizabeth Taylor

Jasmine Guy as Leah Grimes

Chris Sarandon as Mario Barbari

Anthony LaPaglia as Spec Broadwater

John Benjamin Hickey as Theodore Tipton

Judith Ivey as Nan MacChesney

James Hampton as Reverend Manning

Mary Pat Gleason as Alice Lambert

Bridget Gabbe as Tayloe Slagle

Joe Inscoe as Wayne Lambert

Angelina Fiordellisi as Fiammetta Mulligan

Mary Testa as Zia Maria Luisa

Erika Coleman as Pearl Grimes

John S. Rausch as Father John

James Edward Mitchell Jr. as Bobby Dinsmore

Terry Kilgore as Delegate Terry Kilgore

Rickey Wiley as Earl Purvis

Rick Horne as Hal

Lily Kamp as Jenna

Jack McClanahan as Worley Olinger

Ron Flanary as Otto Olinger

Eamonn McCrystal as John Hale

Sharon Watroba as Nellie Goodloe

Brandon Scott Beaty Sr. as PeeWee

Eleanor Jones as Betty Slagle

Kalin Wilson as Jared Tinsley

Kassian Wilson as Chris Tinsley

Heather McElyea Blair as Effie Clasby

Brownie Polly III as John Warner

Matthew Stocke as Johnny Wood

Star Bresee as Misty Cubine

Mary Deese as Dr. Miranda

Greg Kress as Doc Daugherty

Carlo Trigiani as Young Mario Barbari

Jean Williams Hall as Illinois Mitchell

Logan Stuart Baker as Mourner #1

Beatrice Bancroft as Shanna

Adam Chaffin as Coal Miner

Brett Clark as Cool Guy in Truck

Debbie Green as Nurse

Devin Hylton as Coal Miner / Church Member

Sergio Kato as Steve

Aaron Kelly as Funeral Attendee / Party Goer

Gina Owens Stanley as Wedding Guest

Paul Wilson as Lyle Makin