Zoe Saldaña as Nina Simone

David Oyelowo as Clifton Henderson

Mike Epps as Richard Pryor

Ella Thomas as Lorraine Hansberry

Ronald Guttman as Henri Edwards

Ella Joyce as Clifton's Mom

Keith David as Clifton's Father

Mary Pat Gleason as Ordlery Pat

Siena Goines as Heather

Kit Leonard Dennis as Lawyer

Yasmine Golchan as Dr. Cousier