Benedict Cumberbatch as Grinch (voice)

Rashida Jones as Donna Lou Who (voice)

Kenan Thompson as Bricklebaum (voice)

Cameron Seely as Cindy Lou Who (voice)

Angela Lansbury as Mayor McGerkle (voice)

Pharrell Williams as Narrator (voice)

Ramone Hamilton as Axl (voice)

Sam Lavagnino as Ozzy (voice)

Scarlett Estevez as Izzy (voice)

Michael Beattie as Store Clerk (voice)

Scott Mosier as Additional Voices (voice)

Lori Alan as Additional Voices (voice)

Carter Hastings as Additional Voices (voice)

Carlos Alazraqui as Additional Voices (voice)

John Kassir as Additional Voices (voice)

Cathy Cavadini as Additional Voices (voice)

Danny Mann as Additional Voices (voice)

Meilee Condron as Additional Voices (Voice)

Tristan O'Hare as Groopert (voice)

Doug Burch as Additional Voices (voice)

Tucker Chandler as Additional Voices (voice)

Townsend Coleman as Additional Voices (voice)

Abby Craden as Additional Voices (voice)

Brian T. Delaney as Additional Voices (voice)

John DeMita as Additional Voices (voice)

Bill Farmer as Additional Voices (voice)

Aaron Fors as Additional Voices (voice)

Willow Geer as Additional Voices (voice)

Jess Harnell as Additional Voices (voice)

Evan Kishiyama as Additional Voices (voice)

Barbara Harris as Additional Voices (voice)

Jeremy Maxwell as Additional Voices (voice)

Laraine Newman as Additional Voices (voice)

Dashiell Priestley as Additional Voices (voice)

Alex Puccinelli as Additional Voices (voice)

Emma Elizabeth Shannon as Additional Voices (voice)

Joel Swetow as Additional Voices (voice)

Mindy Sterling as Additional Voices (voice)

Tara Strong as Additional Voices (voice)

Regina Taufen as Additional Voices (voice)

Jim Ward as Additional Voices (voice)