Charlie Adler as Buster Bunny / Usher (voice)

Tress MacNeille as Babs Bunny / Big Boo / Babs' Mother / Emily Duff / Roseanne Barr / Barbara Walters / Arsenio Hall / Additional Voices (voice)

Joe Alaskey as Plucky Duck / Tupelo Toad / Johnny Carson / Ed McMahon / Elmer Fudd / Additional Voices (voice)

Don Messick as Hamton J. Pig / Radio Announcer (voice)

Jonathan Winters as Wade Pig / Superman (voice)

Edie McClurg as Winnie Pig (voice)

Frank Welker as Uncle Stinky Pig / Byron Basset / Furrball / Little Beeper / Gogo Dodo / Vinnie / Mac Duff / Additional Voices (voice)

Cree Summer as Elmyra Duff / Mary Melody / Oprah Winfrey (voice)

Sorrell Booke as Big Daddy Boo (voice)

Rob Paulsen as Fowlmouth / Johnny Pew / Banjo the Woodpile Possum / Mr. Hitcher / Manager / Additional Voices (voice)

Maurice LaMarche as Dizzy Devil / David Letterman / Horatio / Theatre Voice (voice)

Gail Matthius as Shirley the Loon / Sissy Boo (voice)

Kath Soucie as Fifi La Fume / Little Boo / Little Sneezer / Bimbette Skunk (voice) (as Kath Souci)

Candi Milo as Sweetie Pie (voice)

Paul Julian as Road Runner (archive sound) (uncredited)