Gena Rowlands as Ivy

Tony Shalhoub as Misha Vilyenkov

Cheech Marin as Ignacio

Bruce Davison as Dr. Reingold

Trini Alvarado as Adult Marie Alweather

Jay Mohr as Benny / Paulie (voice)

Buddy Hackett as Artie

Hallie Eisenberg as Marie Alweather

Matt Craven as Warren Alweather

Bill Cobbs as Virgil the Janitor

Tia Texada as Ruby / Lupe (voice)

Laura Harrington as Lila Alweather

Peter Basch as Graduate Student #1

Emily Mura-Smith as Graduate Student #2

Hal Robinson as Grandpa

Tamara Zook as Speech Therapist

Nicole Chamberlain as Shirley

Charles Parks as Gerald

Seth Mumy as Jeremy

Dig Wayne as Research Assistant #1

Michael Leydon Campbell as Research Assistant #2

Kristie Transeau as Veterinarian

Francesca Federico-O'Murchu as Molly

Jerry Winsett as Mr. Tauper

Bud Cox as Ivy's Doctor