Adam Carolla as Spanky Ham (voice)

Abbey DiGregorio as Ling-Ling (voice)

Jess Harnell as Captain Hero / King / Wile E. Coyote (voice)

Seth MacFarlane as I.S.R.A.E.L. (aka Intelligent Smart Robotic Animated Eraser Lady) (voice)

Jack Plotnick as Xandir P. Whifflebottom (voice)

Tara Strong as Toot Braunstein / Princess Clara (voice)

Cree Summer as Foxxy Love / Suck My Taint Girl (voice)

James Arnold Taylor as Wooldoor Sockbat / Jew Producer / Barney Rubble (voice)

Vernon Wells as Network Head (voice)

Kaitlyn Robrock as Hot Bar Chick / Old Lady #2 / Smurfette (voice) (uncredited)

Dave Jeser as Himself (voice)

Matthew Silverstein as Himself (voice)