James Arness as Zeb Macahan

Eva Marie Saint as Kate Macahan

Bruce Boxleitner as Seth Macahan

Kathryn Holcomb as Laura Macahan

William Kirby Cullen as Jed Macahan

Vicki Schreck as Jessie Macahan

Richard Kiley as Timothy Macahan

Gene Evans as Dutton

John Crawford as Hale Crowley

Victor Mohica as Billy Joe

Frank Ferguson as Grandpa

Ann Doran as Grandma

Vincent St. Cyr as Ponca Chief

Rudy Diaz as Sioux Chief

F. Allen Livers as The Runner

Jim Ward as The Mountain Man

Ben Wilson as Henry Jethro

Skip Lowell as Dying Rebel

Tom Stovall as Rebel #1

Jack Wallwork as C.O. of Fort Randall

Ben Zeller as Cavalry Major

Wright King as Infantry Captain

William Bryant as Major at Shiloh

Mayf Nutter as Jenkins

Henry Olek as Grayson

Charles Kuenstle as Sgt. Hodges

Claude Johnson as Wounded Soldier

Clark Dunbar as Aide

Lloyd Nelson as Sentry

Jonathan Banks as Woodward

Herb Robins as Polk

Joe Kurtzo as Stenner

Cliff Emmich as Bartender

Mel Stevens as Dr. Dodd

Bill Zuckert as Caldwell

Hal Baylor as Lawman

I. Stanford Jolley as Farmer

William Conrad as Narrator (voice) (uncredited)