Mel Blanc as Barney Rubble / Dino / Mr. Spacely (voice)

Daws Butler as Elroy Jetson / W.C. Cogswell / Henry Orbit (voice)

Don Messick as Astro / R.U.D.I / Mac / Announcer / Store Manager / Robot (voice)

Henry Corden as Fred Flintstone / Knight (voice)

Jon Bauman as Iggy (voice)

Hamilton Camp as Turk Tarpit (voice)

Julie McWhirter as Betty Rubble / Jet Rivers / Investor / Panelist / Harem Girl (as Julie Dees) (voice)

George O'Hanlon as George Jetson (voice)

Penny Singleton as Jane Jetson (voice)

John Stephenson as Mr. Slate / Moderator / Investor / Poker Player (voice)

Brenda Vaccaro as Didi (voice)

Jean Vander Pyl as Wilma Flintstone / Rosie / Mrs. Spacely (voice)

Janet Waldo as Judy Jetson / Female Computer (voice)

Frank Welker as Dan Rathmoon / Johnny / Mr. Goldbrick (voice)

Patric Zimmerman as (voice)