Carrie Aizley as Robyn Wexler

Sarah Baker as Mindy Murray

Bob Balaban as Sol Lumpkin

Ed Begley Jr. as A.J. Blumquist

Tom Bennett as Owen Golly, Jnr.

Maria Blasucci as Jessica Mundt

Jennifer Coolidge as Jolene Lumpkin

Kerry Godliman as Sarah Golly

Matt Griesser as Andy Dibble

Christopher Guest as Corky St. Clair

John Michael Higgins as Upton French

Michael Hitchcock as Langston Aubrey

Don Lake as Buddy Campbell

Jane Lynch as Gabby Monkhouse

Christopher Moynihan as Phil Mayhew

Chris O'Dowd as Tommy 'Zook' Zucarello

Jim Piddock as Owen Golly, Sr.

Parker Posey as Cindi Babineaux

Harry Shearer as Competition Announcer (voice)

Fred Willard as Greg Gammons, Jr.

Zach Woods as Mike Murray

Susan Yeagley as Laci Babineaux

Wayne Wilderson as Dr. Harper James

Suanne Spoke as Cavaliers Owner's Wife

Steven M. Porter as Cavaliers Owner

Hayes Mercure as Football Player

Suzi Barrett as 'Does This Smell Normal' Woman

Ryan Gaul as 'Does This Smell Normal' Man

Brooke Hasalton as Bushwackers Lap Dancer

Adam Karchmer as Monty Murray

Zoe Provenzano as Maggie Murray

Karly Rothenberg as Mindy's Mother

Tim Baltz as South Dixie Air Ticket Agent

Kathreen Khavari as Las Palmas Inn Desk Clerk

Ithamar Enriquez as Chicharito's Bouncer

Marilyn Mark as Chicharito's Waitress

Crafty St. James as Gabby's Fan

Tommy Bechtold as Gabby's Fan

Lindsey Warm as Gabby's Fan

Scott Williamson as Bruce Van Wyck

Morgan Obenreder as Nanny

Vic Chao as Bumblebee (uncredited)

Ross Kimball as Police Officer