Al Pacino as Dr. Jack Kevorkian

Danny Huston as Geoffrey Fieger

Susan Sarandon as Janet Good

John Goodman as Neal Nicol

Brenda Vaccaro as Margo Janus

Eric Lange as John Skrzynski

James Urbaniak as Jack Lessenberry

Rutanya Alda as Vendor

Delaney Williams as Detective #1

Danielle McKee as Dorothy Lessenberry

Adam Driver as Glen Stetson

Deirdre O'Connell as Linda

Todd Susman as Stan Levy

Jennifer Mudge as Female Reporter

Jeremy Bobb as David Rivlin

Henny Russell as Oakhill Spokesperson

Henry Strozier as Oakhill Doctor

Sandra Seacat as Janet Adkins

Neil Brooks Cunningham as Rod Adkins

David Wilson Barnes as David Gorcyca

Cotter Smith as Dick Thompson

John Rue as Ray Good

Allen Lewis Rickman as Dr. Dragovic

Kris Eivers as Deputy

Richard Council as Judge David Breck

Jason Babinsky as Detective

Teresa Yenque as Isabel Correa

Jamie Tirelli as Trino Correa

John Henry Cox as Mr. Kinsey

Ana Reeder as Lynn Mills

Jonathan Teague Cook as Hugh Gale

Tom Kemp as Carl Marlinga

Jordan Lage as Beaumont Doctor

Mason Pettit as Construction Worker

Daryl Edwards as Judge Jackson

Meghan Rafferty as Female Reporter

Deborah Hedwall as Melody Youk

Rondi Reed as Judge Cooper

Adam Mucci as Dave Gorosh

Bill Edwards as On-the-Street Interviewee

Kevin Cannon as Defendant (uncredited)

Peter Conboy as Oakland County Deputy (uncredited)

John Farrer as Hemlock Society Member (uncredited)

Renee Fishman as Stenographer (uncredited)

Jacqueline Forton as Protester (uncredited)

Rennel Turner as Protester (uncredited)

Moe Hindi as Paparazzi Photographer (uncredited)

Kevin Janaway as Celebrity Party-Goer (uncredited)

Joseph John Justin as Inmate (uncredited)

Frosty Lawson as Background with Car (uncredited)

Addison LeMay as Reporter (uncredited)

Bill Lumbert as Supporter (uncredited)

Dwayne Roszkowski as Gentleman at Courthouse (uncredited)

Bill Walters as Michigan Inmate (uncredited)