Johnny Depp as Sherlock Gnomes (voice)

Emily Blunt as Juliet (voice)

James McAvoy as Gnomeo (voice)

Chiwetel Ejiofor as Watson (Voice)

Mary J. Blige as Irene (voice)

Stephen Merchant as Paris (voice)

Michael Caine as Lord Redbrick (voice)

Dexter Fletcher as Gargoyle Reggie (voice)

James Hong as Salt Shaker (voice)

Ashley Jensen as Nanette (voice)

Matt Lucas as Benny (voice)

Ozzy Osbourne as Fawn (voice)

Maggie Smith as Lady Bluebury (voice)

Julie Walters as Mrs. Montague (voice)

Jamie Demetriou as Moriarty (voice)

Richard Wilson as Mr. Capulet (voice)

Kelly Asbury as Goons

Gang Chi as Video Game Player (voice)

Julio Bonet as Mankini (voice)

Rosalie Craig as Nimrod Captain (voice)

Eve Webster as Mrs. Udderson - Big Eared Gnome (voice)

Michaël Grégorio as (voice) (uncredited)

Flora Coquerel as (voice) (uncredited)

Diouc Koma as (voice) (uncredited)