Rajinikanth as Dr. Vaseegaran / Chitti / Kutti

Akshay Kumar as Pakshi Rajan

Amy Jackson as Nila

Sudhanshu Pandey as Dhinendra 'Dhina' Bohra

Adil Hussain as Home Minister

Kalabhavan Shajon as Vaira Moorthy

Kaizaad Kotwal as Ranjeet Lulla

Ishari. K. Ganesh as Jeyanth Kumar

Ananth Narayan Mahadevan as Meeting Chairperson

Mayilsamy as Minister of Telecommunications' PA

Michael Muthu as Police Officer

Sanchana Natarajan as One of the students in Dr.Vaseegaran's lab

Raveena Ravi as Nila (voice)

Savitha Reddy as Sana (voice)

Maya S. Krishnan as College Student