Kate Mara as Lee Weathers

Anya Taylor-Joy as Morgan

Toby Jones as Dr. Simon Ziegler

Rose Leslie as Dr. Amy Menser

Boyd Holbrook as Skip Vronsky

Michelle Yeoh as Dr. Lui Cheng

Jennifer Jason Leigh as Dr. Kathy Grieff

Paul Giamatti as Dr. Alan Shapiro

Michael Yare as Ted Brenner

Chris Sullivan as Dr. Darren Finch

Vinette Robinson as Dr. Brenda Finch

Brian Cox as Jim Bryce

Crispian Belfrage as Charles Grimes

Amybeth McNulty as Morgan (age 10)

Jonathan Aris as David Chance

Charlotte Asprey as Executive Assistant

Frank Cannon as CIA Agent