Toshirō Mifune as Dr. Kyojio Niide ("Red Beard")

Yūzō Kayama as Dr. Noboru Yasumoto

Tsutomu Yamazaki as Sahachi

Reiko Dan as Osugi

Miyuki Kuwano as Onaka

Kyōko Kagawa as Madwoman ("The Mantis")

Tatsuyoshi Ehara as Genzô Tsugawa

Terumi Niki as Otoyo

Akemi Negishi as Okuni

Yoshitaka Zushi as Chobo

Yoshio Tsuchiya as Dr. Handayû Mori

Eijirō Tōno as Goheiji

Takashi Shimura as Tokubei Izumiya

Chishū Ryū as Mr. Yasumoto

Haruko Sugimura as Kin, the madam

Kinuyo Tanaka as Madame Yasumoto

Eijirō Yanagi as Madwoman's father

Kōji Mitsui as Heikichi

Kō Nishimura as Chief retainer

Nobuo Chiba as Matsudaira

Kamatari Fujiwara as Rokusuke

Ken Mitsuda as Genpaku Amano

Yōko Fujiyama as Chigusa, Masae's sister

Yōko Naitō as Masae

Reiko Nanao as Otoku

Imari Tsuji as Okatsu

Akiko Nomura as Ofuku

Sue Mitobe as Otake

Kin Sugai as Choji's Mother

Michiko Araki as Brothel owner

Bokuzen Hidari as Patient A

Atsushi Watanabe as Patient B

Yasuzō Ogawa as Businessman

Yutaka Sada as Resident

Ikio Sawamura as Resident

Noriko Honma as Resident

Miyoko Nakamura as Okoto

Akiko Kazami as Masae's mother

Chisato Aoki as Prostitute

Kyoko Kurisu as Prostitute

Yukiko Yanagishita as Prostitute

Toshiko Fukai as Prostitute

Keiko Tomita as Girl on street

Shōji Ōki as Thug

Shōichi Hirose as Thug

Hiroyoshi Yamaguchi as Thug

Masanobu Ōkubo as Choji's Father

Fujio Tokita as Thug

Yasuo Araki as Thug

Hiroshi Tanaka as Thug

Shin Ibuki as Thug

Kanzō Uni as Thug

Hiroto Kimura as Thug

Shu Komoro as Thug

Ryū Kuze as Thug

Susumu Ishikawa as (uncredited)