Will Forte as MacGruber

Kristen Wiig as Vicki

Ryan Phillippe as Piper

Powers Boothe as Colonel Faith

Maya Rudolph as Casey

Chris Irvine as Frank Korver

Mark Henry as Tut Beemer

Glenn Jacobs as Tanker Lutz

Dalip Singh as Tug Phelps

Hassan Hamin Assad as Vernon Freedom

Paul Wight as Brick Hughes

Timothy V. Murphy as Constantine

Andy Mackenzie as Hoss

Jasper Cole as Zeke

Val Kilmer as Cunth

Rhys Coiro as Yerik Novikov

Kevin Skousen as Senator Garver

Robert M. Reid as Priest

Jim Giesler as Janitor

Brandon Trost as Brick's Boyfriend

Robert Douglas Washington as Cashier

Chris Kittinger as Man in Tuxedo

Marielle Heller as Clocky

Derek Mears as Large Henchman

John Gibson as Dealer

Vic Browder as Control Room Guard

Russ Dillen as Commander

Michael-David Aragon as Machine Room Guard

Gregory Alan Williams as Minister

Chad Brummett as Military Officer

Sandra Wood as Nude Model

Matt Wood as Bartender

Mark Dimitrijevic as Man in Café

Amar'e Stoudemire as Self

Brian Petsos as Dude

Alan D'Antoni as Russian Guard

Cajardo Lindsey as Railroad Guard #1

Laurence Chavez as Railroad Guard #2 / Compound Guard #2

Matthew Lee Christmas as Railroad Guard #3

Michael Owen as Railroad Bodyguard

Ed Duran as Compound Guard #1

Tomas Sanchez as Compound Guard #3

Bobby Burns as Compound Guard #4

Bill Leaman as Compound Guard #5

Willie Weber as Compound Guard #6

Alan Tafoya as Charging Guard

Michelle Waterson-Gomez as Club Babe #1

Jason Trost as Smoking Guard

Milos Milicevic as KFBR392 Guy

Christina Rouner as News Anchor

Eugene Nosoff as Russian Radio Voice (voice)

Jamie Haqqani as Wedding Guest (uncredited)

Jesus Jr. as Edwin Culebra (uncredited)

Cynthia Lee as Wedding Guest (uncredited)

Casey Messer as Cunth's Daughter (uncredited)

Freddy Martinez as MMA Fighter (uncredited)