Woody Harrelson as Dr. Michael Reynolds

Jon Seda as Brandon 'Blue' Monroe

Anne Bancroft as Dr. Renata Baumbauer

Alexandra Tydings as Victoria Reynolds

Matt Mulhern as Dr. Chip Byrnes

Talisa Soto as Navajo Woman

Richard Bauer as Dr. Bradford

Victor Aaron as Webster Skyhorse

Lawrence Pressman as Agent in Charge Collier

Michael O'Neill as Agent Moreland

Harry Carey, Jr. as Cashier

Carmen Dell'Orefice as Arabella Reynolds

Brooke Ashley as Calantha Reynolds

Andrea Roth as Head Nurse

Bob Minor as Deputy Lynch

Sal Landi as Deputy #2

Harper Roisman as Mr. Vogel

Kelly Perine as Fellow in Oncology

Andy Berman as Fellow in Oncology

Kirsten Getchell as Sally Byrnes

Emil Alexander as Waiter

John Christian Graas as Young Michael Reynolds

Christopher Masterson as Jimmy Reynolds

Antwon Tanner as Smokes

Pam Morton as Self

Linda M. Duenas as Waitress

Tony Epper as Hay Hauler

Mickey Jones as Fuzzy, Biker #1

Gregory Scott Cummins as Biker #2

Douglas B. Hall as State Trooper

Dan B. Pastre as State Trooper

Elaine Kagan as Woman at Gas Station

Robert 'Bobby Z' Zajonc as FBI Helicopter Pilot

Jeri Arredondo as Hospital Pharmacist

Brian Bossetta as Hospital Security Guard

Cynthia Allison as CNN Reporter

Carolyn Tomlin as Hospital Spokesperson

Brian K. Francis as Navajo Boy

Alan Keller as Older Highway Patrol Officer

Brett Harrelson as Younger Highway Patrol Officer

Zoe Trilling as Mini-Mart Cashier

Betty Carvalho as Rosa

Matthew Abe as Surgeon

Eugene Boggs as Surgeon

Philip Zachary as Disc Jockey

David Green as First Inmate

Askia Won-Ling Jacob as UCLA Student

Robert Downey Sr. as Telephone Voices