Jaeden Martell as Henry Carpenter

Naomi Watts as Susan Carpenter

Maddie Ziegler as Christina Sickleman

Jacob Tremblay as Peter Carpenter

Sarah Silverman as Sheila

Lee Pace as Dr. David Daniels

Dean Norris as Glenn Sickleman

Bobby Moynihan as John

Tonya Pinkins as Principal Wilder

Geraldine Hughes as Mrs. Evans

Jackson Nicoll as Morris

Joel Marsh Garland as Big Ed

Wass Stevens as Gary

Marjan Neshat as Nurse Kathy

Maxwell Simkins as Tommy

Donnetta Lavinia Grays as Nurse Leah

Mary Joy as Dot

Mike Massimino as Trucker

Deborah Rayne as EMT

Zandi Holup as Teenage Girl Customer

Arthur French as Gus

Donna Mitchell as Bookstore Clerk

Taylor Dior as Talent Show Singer

Lily Peterson as Stage Manager (uncredited)

Stefanie Flores as Girlfriend (uncredited)

Logan Smith as Boy (uncredited)

Philip Smreck as George Sickleman

Peter Hourihan as Cop

Gavin Barnes as Kid with 'R'