Naomi Watts as Susan Carpenter

Jaeden Martell as Henry Carpenter

Jacob Tremblay as Peter Carpenter

Sarah Silverman as Sheila

Lee Pace as Dr. David Daniels

Maddie Ziegler as Christina

Dean Norris as Glenn Sickleman

Bobby Moynihan as John

Tonya Pinkins as Principal Wilder

Geraldine Hughes as Mrs. Evans

Maxwell Simkins as Tommy

Jackson Nicoll as Morris

Donnetta Lavinia Grays as Nurse Leah

Joel Marsh Garland as Big Ed

Wass Stevens as Gary

Arthur French as Gus

Mary Joy as Dot

Zandi Holup as Teenage Girl Customer

Mike Massimino as Trucker

Donna Mitchell as Bookstore Clerk

Marjan Neshat as Nurse Kathy

Taylor Dior as Talent Show Singer

Philip Smreck as George Sickleman

Deborah Rayne as EMT

Peter Hourihan as Cop

Gavin Barnes as Kid with "R"

Logan Smith as Boy (uncredited)

Stefanie Flores as Girlfriend (uncredited)

Lily Peterson as Stage Manager (uncredited)