Owen Wilson as Marmaduke (voice)

Emma Stone as Mazie (voice)

George Lopez as Carlos (voice)

Caroline Sunshine as Barbara Winslow

Finley Jacobsen as Brian Winslow

Steve Coogan as Raisin (voice)

Christopher Mintz-Plasse as Giuseppe (voice)

Fergie as Jezebel (voice)

Kiefer Sutherland as Bosco (voice)

Lee Pace as Phil Winslow

Judy Greer as Debbie Winslow

Damon Wayans Jr. as Thunder (voice)

Marlon Wayans as Lightning (voice)

Sam Elliott as Chupadogra (voice)

William H. Macy as Don Twombly

David Walliams as Anton Harrison

Glenn McCuen as Bodie

Raugi Yu as Drama Trainer

Chris Colfer as Drama Dog #2 (voice)

Josh Gad as Bandana Dog (voice)

Ash Lee as Male Executive

Heather Doerksen as Female Executive

Madison Desjarlais as Brunette Girl

Nicole Muñoz as 3rd OC Girl

Christopher Attadia as Jock

Jason Bryden as Man on Bench

Frank Topol as Buff Owner

Izaak Smith as Basketball Captain

Keith Dallas as Emergency Road Worker

P.J. Prinsloo as Lead Fireman

Colin Decker as Fireman

Charles Jarman as Fireman

Garvin Cross as Fireman

Chris Bradford as Fireman

Hope Levy as Afghan #1 (voice)

Randall Montgomery as Sweater Dog (voice)

Anjelah Johnson-Reyes as Afghan #2 (voice)

Devon Werkheiser as Drama Dog #1 / Shroom Dog #2 / Golden Dog / Cocker Spaniel (voice)

Hudson Thames as Delinquent Dog (voice)

Francisco Ramos as Purse Dog #1 (voice)

Bernardo de Paula as Purse Dog #2 (voice)

Eddie 'Piolin' Sotelo as Purse Dog #3 (voice)

Jack McGee as Dalmatian (voice)

Liza Lapira as Party Dog #1 (voice)

King Kedar as Surfing Award Dog / Beach Dog #4 (voice)

Todd Glass as Doberman / Shasta (voice)

Ryan Devlin as Beach Dog #2 (voice)

Jeffrey Garcia as Beach Dog #3 (voice)