John Wayne as John Chisum

Forrest Tucker as Lawrence Murphy

Christopher George as Dan Nodeen

Ben Johnson as James Pepper

Glenn Corbett as Pat Garrett

Andrew Prine as Alex McSween

Bruce Cabot as Sheriff Brady

Patric Knowles as Henry Tunstall

Richard Jaeckel as Jess Evans

Lynda Day George as Sue McSween

Geoffrey Deuel as Billy 'The Kid' Bonney

Pamela McMyler as Sallie Chisum

John Agar as Amos Patton

Lloyd Battista as Neemo

Robert Donner as Bradley Morton

Christopher Mitchum as Tom O'Folliard

Edward Faulkner as James J. Dolan

Ray Teal as Justice J.B. Wilson

Ron Soble as Charley Bowdre

John Mitchum as Baker

Glenn Langan as Colonel Nathan Dudley

Alan Baxter as Gov. Sam Axtell

Alberto Morin as Juan Delgado

William Bryant as Jeff - Head Wrangler

Pedro Armendáriz Jr. as Ben

John Pickard as Sgt. Braddock

Abraham Sofaer as Chief White Buffalo

Gregg Palmer as Karl Riker

Hank Worden as Stationmaster Elwood

Pedro Gonzalez Gonzalez as Mexican Rancher

Jim Burk as Trace - Wrangler

Eddy Donno as Cass

Bob Morgan as Pegleg on Street

William Conrad as Narrator - Opening Credits (voice) (uncredited)

José Ángel Espinosa 'Ferrusquilla' as Governor's Aide (uncredited)

Ron Fletcher as Doctor (uncredited)

'Chico' Hernandez as Boy on Town (uncredited)

John Kelly as Minister (uncredited)

Cliff Lyons as Wrangler (uncredited)

Josh McLaglen as Young Boy Loading Wagon (uncredited)

Mary McLaglen as Young Girl (uncredited)

Lee Meriwether as Sallie's Mother (picture in Chisum's Pocketwatch) (uncredited)

Chuck Roberson as Trail Herder (uncredited)

José Torvay as Mexican Blacksmith (uncredited)

José Trinidad Villa as Blacksmith (uncredited)

Ralph Volkie as Blacksmith (uncredited)

Henry Wills as Extra (uncredited)