Fiona Dourif as Nica Pierce

Brad Dourif as Chucky (voice)

Alex Vincent as Andy Barclay

Jennifer Tilly as Tiffany Valentine

Michael Therriault as Dr. Foley

Adam Hurtig as Michael

Elisabeth Rosen as Madeline

Zak Santiago as Nurse Carlos

Ali Tataryn as Nurse Ashley

Grace Lynn Kung as Claire

Marina Stephenson Kerr as Angela

Allison Dawn Doiron as Rachel

Summer H. Howell as Alice Pierce

Tom Anniko as Chaplain

Darren Wall as Asylum Guard

Dan De Jaeger as Orderly #1

Matthew Stefanson as Orderly #2

Dennis Scullard as Asylum Patient (uncredited)

Aidan Ritchie as Asylum Patient (uncredited)

Linden Porco as Body (uncredited)

Lorrie Papadopoulos as Asylum Patient (uncredited)

Paolo Bryant as Orderly (uncredited)

Christine Elise as Kyle