Michelle Rodriguez as Frank Kitchen / Tomboy

Sigourney Weaver as Dr. Rachel Kay

Tony Shalhoub as Dr. Ralph Galen

Caitlin Gerard as Johnnie

Anthony LaPaglia as Honest John Hartunian

Paul McGillion as Paul Wincott

Ken Kirzinger as Nurse Albert Becker

Paul Lazenby as Bodyguard

Zak Santiago as Edward Gonzales

Adrian Hough as Sebastian

Alex Zahara as Vladimir Gorski

Chad Riley as Merchado

Jason Asuncion as Hiram Ko (Dog Trainer)

Darryl Quon as Jin Tao

Hugo Ateo as Guzman

Sergio Osuna as Mexican Man

Terry Chen as Dr. Lin

Lauro David Chartrand-DelValle as Cousin in Vegas

Caroline Chan as Ting Li

Lia Lam as Asian woman

Eltie Pearce as Whitney