Melissa McCarthy as Deanna Miles

Matt Walsh as Dan Miles

Molly Gordon as Maddie Miles

Gillian Jacobs as Helen

Luke Benward as Jack Strong

Maya Rudolph as Christine Davenport

Julie Bowen as Marcie Strong

Jacki Weaver as Sandy Cook

Stephen Root as Mike Cook

Adria Arjona as Amanda

Jessie Ennis as Debbie

Heidi Gardner as Leonor

Debby Ryan as Jennifer

Chris Cavalier as Eugene

Jimmy O. Yang as Tyler

Chris Parnell as Mr. Truzack (Wayne)

Yani Simone as Trina

Mac Alsfeld as Hench

Damon Jones as Frank Davenport

Karina Delbeau-Charles as Carol

Michele Jang as Linda

Steve Mallory as Bill

Courtney Patterson as Amy

Nat Faxon as Lance

Sarah Baker as Gildred

Ben Falcone as Uber Driver (Dale)

Steve Falcone as Old Man #1/Vince

Michael D. McCarthy as Old Man #2/Dennis

Flynn Falcone as Guidance Counselor

Julie Coile as Bookstore Cashier

Karen Maruyama as Mediator

Kevin Gutierrez as Water Bottle Student

Seth Dousman as College Kid #1

Antonio Bell as Drunk Guy at Sorority Party

Sheila Maddox as Graduation Speaker

Dytto as Dancer

Frankie Freeman as Dancer

Naeemah McCowan as Dancer

Xavier Wilcher as Dancer

Jae Scott as Dancer

Jordan Galloway as Dancer

Ahmed Zakzouk as Dancer

Christina Aguilera as Self (uncredited)

Raven Wynn as Jennifer's Friend #1 (uncredited)