Nicolas Cage as Brent Ryan

Selma Blair as Kendall Ryan

Anne Winters as Carly Ryan

Zackary Arthur as Joshua Ryan

Robert T. Cunningham as Damon Hall

Olivia Crocicchia as Riley

Lance Henriksen as Mel Ryan

Marilyn Dodds Frank as Barbara Ryan

Samantha Lemole as Jenna

Joseph D. Reitman as Homeroom Teacher

Rachel Melvin as Jeannie

Brionne Davis as Tanner

Bobby Richards as Dan

Mehmet Oz as Dr. Mehmet Oz

Grant Morrison as Expert

Sharon Gee as Sun-Yi

Edwin Lee Gibson as Mr. Hall

Adin Steckler as Jin-Lisa

Cassidy Slaughter-Mason as Madison

George Griffith as Doctor

Sheri Hawthorne Carbone as Mrs. Winslow

Lila Tellone as Young Carly

Christine Dye as Administrator

Lorena Diaz as Nurse

Rob Gough as Police Officer

Angela Diehl Forman as Parent

Angie Fenton as Interviewer

Michael Yurchak as Pool Dad

Bishop Stevens as Crazed Dad / Mr. Stevens (uncredited)

Michael Yurchak as Dad in Pool (uncredited)

Dale Miller as Gym Teacher (uncredited)

Emmalee Parker as High School Student (uncredited)

Brett Mahoney as Hospital Visitor (uncredited)

Charles Poole as Parent (uncredited)

Tyler Sopland as Student (uncredited)

Katie Stewart as Student / Runner (uncredited)

Angie Willmott as Zumba Dancer (uncredited)

Bokeem Woodbine as Parent on TV (uncredited)

Cacia Rose as Trans-Am Girl (uncredited)

Andreea Marcu as Tanner's Assistant