Cate Blanchett as Bernadette

Billy Crudup as Elgie

Kristen Wiig as Audrey

Judy Greer as Dr. Kurtz

Laurence Fishburne as Paul Jellinek

Emma Nelson as Bee

Troian Bellisario as Becky

James Urbaniak as Agent Marcus Strang

Megan Mullally as Judy Toll

Richard Robichaux as Floyd the Pharmacist

Kate Burton as Ellen Idelson

Steve Zahn as David Walker

David Paymer as Jay Ross

Zoë Chao as Soo-Lin

Patrick Sebes as Tom the Blackberry Guy

Lee Harrington as USC Student

Patrick Jordan as Game Show Host

Shaun Cameron Hall as Pablo

Kathryn Feeney as Tamara the Pharmacy Employee

Amy Rayko as Lisa Prospective Parent

Nancy McNulty as Lori Prospective Parent

Daina Griffith as Julie Prospective Parent

Kate Easton as Tammy Prospective Parent

Stephen Donnelly as Mr. Hayes

Thalia Torio as Kennedy

Mark Philip Stevenson as Architectural Expert

Cherie McClain as News Reporter

Maureen d'Armand as Crew Member Allegra

Jóhannes Haukur Jóhannesson as Captain J. Rouverol

Claudia Doumit as Iris

Katelyn Statton as Vivian

Jennifer Tober as Snappy Tourist Lady

Joe Coyle as Mike the State Senator

Alan Lee Baker as Construction Worker (uncredited)

Richard Barlow as Stu Reardon (Microsoft Executive) (uncredited)

Heidi Barrientes as Airport Traveler / Taxi Passenger (uncredited)

Tom Bonello as Pharmacy Patron (uncredited)

Brian 'Wolfman Black' Bowman as Parent (uncredited)

Chris Breen as Audience Member (uncredited)

Gregory Bromfield as Caterer (uncredited)

Zachary Davis Brown as Kyle's Friend (uncredited)

Owen Buckenmaier as Kyle (uncredited)

Isaac J. Conner as Passenger (uncredited)

Erik J. Cornelius as Baggage Handler (uncredited)

Kelli Culbertson as Restaurant Patron (uncredited)

Bruce Curtis as Nigel Mills-Murray (uncredited)

Kelley Davis as Passenger (uncredited)

Chris Drexel as Restaurant Patron (uncredited)

Grant Eastey as Restaurant Patron (uncredited)

Amy Lyn Elliott as Flight Attendant (uncredited)

Russell Bradley Fenton as Gary Oppenheimer (uncredited)

Joe Fishel as Galer Street School Parent (uncredited)

Simone Bruyère Fraser as Restaurant Patron (uncredited)

Emir García as Pedestrian (uncredited)

Peter Georgo as Tech Enthusiast / Party Goer (uncredited)

Elijah Goulet as School Child (uncredited)

Ben Guenther as TED Talk Attendee (uncredited)

Juliane Hagn as Airport Traveler (uncredited)

Rene Hamlet as Traveler (uncredited)

Joely Haregsin as Jellinek's Student (uncredited)

Mike D Harris as Coffee Shop Patron (uncredited)

Andrew Harvey as Tourist in Boat (uncredited)

Adam Hicks as Parent (uncredited)

Jagger Hicks as Student (uncredited)

Liz Higgins as Traveler (uncredited)

Anthony Holland as Beeber Construction Worker (uncredited)

Tara O. Horvath as Airport Patron (uncredited)

Wesley Jansen as Pedestrian (uncredited)

Nagy Jay as Restaurant Patron / TED Talk Attendee (uncredited)

Morgen Johnson as Space Needle Restaurant Patron (uncredited)

Brett Kennedy as Naturalist (uncredited)

Trudi Kennedy as TED Talk Attendee (uncredited)

Micah Knapp as Airline Passenger (uncredited)

Tiahna Kovarik as Airline Passenger (uncredited)

Mike Kuse as TED Talk Attendee (uncredited)

Daniel Lamont as Construction Worker (uncredited)

Susan Lang as Cruise Ship Passenger (uncredited)

James Lloyd as Crossing Guard (uncredited)

Chelsea Long as Parent (uncredited)

Theresa Mangus as Game Show Contestant (uncredited)

F. Robert McMurray as Airplane Passenger (uncredited)

Sue Danna Myer as TED Talk Attendee (uncredited)

Adam Nakanishi as Microsoft Worker (uncredited)

Amy Nelson as T-Shirt Mom (uncredited)

Vanessa N. Nelson as Airline Passenger (uncredited)

Ted Opalinski as TED Talk Attendee / Party Patron (uncredited)

Martin A. Palma as Parent (uncredited)

Michael Paradise as Construction Worker (uncredited)

Edward Pfeifer as Bus Passenger (uncredited)

Jacob Phelps as Airline Employee (uncredited)

Rebecca Phipps as Port Lockroy Tourist (uncredited)

Dwayne Pintoff as Tourist (uncredited)

Elizabeth Rhoades as Pedestrian (uncredited)

Mario Ruiz as Beeber Construction Worker (uncredited)

Edlyn Sabrina as Party Guest (uncredited)

Erika Shrout as Game Show Model (uncredited)

Liam Sigman as Airline Passenger (uncredited)

Brian E Stead as Bus Passenger (uncredited)

Kyle Stoltz as Airline Passenger (uncredited)

Long Tran as Restaurant Patron (uncredited)

Nicole Tubbs as TED Talk Attendee (uncredited)

Jessica Ureste as Airline Passenger (uncredited)

Noah J. Welter as Jellinek Student (uncredited)

Joe Wos as Parent (uncredited)

Zoe Xandra as Caterer (uncredited)

Lana Young as Elaine the Airline Woman (uncredited)

Camden Zapf as Cafeteria Kid (uncredited)

Jean Zarzour as Passenger (uncredited)

Donald Zoffel as Student (uncredited)