Harry Dean Stanton as Lucky

David Lynch as Howard

Ron Livingston as Bobby Lawrence

Ed Begley Jr. as Dr. Kneedler

Tom Skerritt as Fred

Barry Shabaka Henley as Joe

James Darren as Paulie

Beth Grant as Elaine

Yvonne Huff Lee as Loretta

Hugo Armstrong as Vincent

Bertila Damas as Bibi

Pamela Sparks as Pam

Mouse as Mouse

Ulysses Olmedo as Juan Wayne

Ana Mercedes as Victoria

Sarah Cook as Debbie

Amy Claire as Frances

Otti Feder as Woman With Walker

Fiona as Fiona

Alan Corvaia as Vero (uncredited)

Johnny Glasser as Background (uncredited)

Dan Gruenberg as Laughing Barfly (uncredited)

Mikey Kampmann as Hipster (uncredited)

Daniel R. Lawson Jr. as Patron (uncredited)

Kim Kaycee Page as Susan (uncredited)

Rhandy Torres as TV Producer (uncredited)

Liberace as Self (archive footage) (uncredited)