Storm Reid as Meg Murry

Oprah Winfrey as Mrs. Which

Reese Witherspoon as Mrs. Whatsit

Mindy Kaling as Mrs. Who

Levi Miller as Calvin O'Keefe

Deric McCabe as Charles Wallace Murry

Chris Pine as Dr. Alex Murry

Gugu Mbatha-Raw as Dr. Kate Murry

Zach Galifianakis as The Happy Medium

Rowan Blanchard as Veronica Kiley

Michael Peña as Red

André Holland as Principal Jenkins

Bellamy Young as Camazotz Woman

David Oyelowo as The It (voice)

Conrad Roberts as Elegant Man

Lyric Wilson as Young Meg

Yvette Cason as Mrs. Teacher

Will McCormack as Mr. Teacher

Daniel MacPherson as Calvin's Father

Akemi Look as Air Force Officer

Tim Kang as School Superintendent

Michele Norris as Radio News Broadcaster (voice)

Claire Montwill as Student

Catelynn Brown as Meg Double

Ariyah Brown as Meg Double

Losa Fifita as Meg Double

Joyce Larkin as Mrs. Who Double

Teonee Motley as Mrs. Which Double

Jessica Rockwell as Mrs. Whatsit Double

Oz Kalvan as Charles Wallace Double

Isaac Ordonez as Charles Wallace Double

Kai Miller as Charles Wallace Double

Leighton Leevard as Charles Wallace Double

Guillaume Seeleuthner as Charles Wallace Double

Jacob Eddington as Charles Wallace Double

Easton Tath as Baby Charles Wallace

Giselle Paredes as Baby Charles Wallace

Punnavith Koy as