Donald Sutherland as Brother Thadeus

John Heard as Brother Timothy

Andrew McCarthy as Michael Dunn

Mary Stuart Masterson as Danni

Kevin Dillon as Rooney

Malcolm Danare as Caesar

Jennifer Dundas as Boo

Kate Reid as Grandma

Wallace Shawn as Father Abruzzi

Jay Patterson as Brother Constance

George Anders as Brother Augustus

Dana Barron as Janine

John Eric Bentley as First Man

Imogene Bliss as Cook

Philip Bosco as Brother Paul

Donald Breitman as Brother Gregory

Nolan Carley as Bartender

Al Cerullo as Pilot

Calvert DeForest as Bridge Operator

Patrick Dempsey as Corbet

Christopher Durang as Priest

William Eustace as Brother William

Henry Fehren as Priest Celebrant

Janice Fuller as Passenger

Pamela Galvin as Sister Thomasina

Stephen Geoffreys as Williams

Richard Hamilton as Grandpa

Jody Jensen as Girl #2

Mary Koch as Cafeteria Lady

Paul Marchand as Perrin

Kachina Myers as Girl #1

Vic Polizos as Police Officer

Douglas Seale as Brother Domenic

Yeardley Smith as Cathleen

Jimmie Ray Weeks as Danni's Father

Mel Winkler as Willie

Ed Zang as Confessor

Craig Austin as High School Student (uncredited)

Victoria Boa as Catholic School Girl (uncredited)

Nancy Cartwright as Girl at Dance (uncredited)

Kathleen Gati as Catholic School Girl (uncredited)

George Gerard as High School Student (uncredited)

Keith Nisonoff as Steve (uncredited)

Jared Simon as Prep Student (uncredited)

Thomas E. van Dell as Student (uncredited)

Maggie Wagner as Catholic School Girl (uncredited)

Anthony Welch as Catholic School Student (uncredited)